|
TNF RECEPTOR BINDING, ALTERED
|
0.100 |
CausalMutation
|
phenotype |
CLINVAR |
|
|
|
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
At baseline, TTP and HuR gene expression levels, as well as the TTP:TNFalpha, TTP:HuR, and TIA-1:TNFalpha gene expression ratios were lower in patients with RA than in control subjects, while expression of TNFalpha, TIA-1, and TIA-1:HuR was higher in patients with RA.
|
17599736 |
2007 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
PreproET mRNA expression increased in PBMCs from rheumatoid arthritis (RA) patients but returned to basal level in PBMCs from patients under anti-TNF therapy.
|
22249931 |
2012 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
This study investigated the added value of US to clinical variables in predicting flare in RA patients with longstanding low disease activity when stopping TNF inhibitors (TNFi).
|
28595367 |
2017 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Elevated TNF-α expression has been found to be associated with the development of diabetes, septic shock, tumorigenesis, cardiovascular diseases, rheumatoid arthritis and inflammatory bowel disease.
|
22650374 |
2012 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
TNF-α mRNA levels showed a clear 24-h rhythm with a peak at 22 HALO and a trough at 18 HALO after RA had developed.
|
21452922 |
2011 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Expression of monocyte chemotactic and activating factor in rheumatoid arthritis. Regulation of its production in synovial cells by interleukin-1 and tumor necrosis factor.
|
8507217 |
1993 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In contrast, RA FLS were particularly sensitive to the synergistic increase of Shn3 with TNF-α and IL-17A.
|
27072520 |
2016 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We measured serum levels of interleukin 6 (IL-6), IL-8, and tumor necrosis factor (TNF-alpha) by immunochemiluminescence method and serum IL-18 levels by ELISA in 50 patients with active untreated AOSD, 20 patients with active rheumatoid arthritis (RA), and 20 healthy controls.
|
15517632 |
2004 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Pyk2 and Src were phosphorylated more on RA versus OA and ND lining cells and MPhis. pPyk2 was expressed on RA ST fibrobasts but not in MPhis at baseline, however it was upregulated upon TNFalpha or IL1beta activation in both cell types. pSrc was expressed in RA ST fibroblasts and MPhis at baseline and was further increased by TNFalpha or IL1beta stimulation. pPaxillin and pPLCgamma were upregulated in RA versus OA and ND lining cells and sublining MPhis.
|
17963503 |
2007 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The TNF-α level in AS was significantly lower than that in RA (p = 0.016).
|
31830775 |
2020 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Before treatment RA neutrophils exhibited increased TNF mRNA expression, elevated mTNF levels and NF-κB activity compared with controls.
|
21109521 |
2011 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
However, PG- and LPS-induced TNFalpha expression and IL-8 expression were greater with RA SF macrophages than with those obtained from the joints of patients with other forms of inflammatory arthritis or with control macrophages.
|
17599732 |
2007 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
VEGF expression is enhanced by TNF-α, the main pro-inflammatory cytokine in RA.
|
23684916 |
2013 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
MiR-155 expression was increased in RA compared to controls [median/IQR 6 (3.5-8.1) vs. 1.0 (0.95-1.6), p < 0.001] and correlated with TNF-α and IL-1β (both r = 0.94, p < 0.001).
|
28782994 |
2017 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, expression of TNFα and IL-6 correlated significantly with IL-32γ expression in RA, whereas this was not observed for IL-32β.
|
21383200 |
2011 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
On the other hand, ADAM15 expression in RA synovial fibroblasts was enhanced with VEGF165 only if vascular endothelial growth factor receptor (VEGFR)-2 expression was induced by treatment with tumor necrosis factor-alpha, and the expression was blocked with SU1498, a specific inhibitor of VEGFR-2.
|
16277668 |
2005 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Cytokines in chronic inflammatory arthritis. VI. Analysis of the synovial cells involved in granulocyte-macrophage colony-stimulating factor production and gene expression in rheumatoid arthritis and its regulation by IL-1 and tumor necrosis factor-alpha.
|
2026869 |
1991 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The production of IL-34 in FLS was up-regulated by TNFα in RA samples compared with osteoarthritis (OA) patients.
|
22264405 |
2012 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We discovered 280 TNF-inducible arthritogenic genes which are transiently expressed and subsequently repressed in macrophages, but in RA, FLS are expressed with prolonged kinetics that parallel the unremitting kinetics of RA synovitis.
|
31097419 |
2019 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In summary, the ability of IL-1 and TNF to preferentially induce stromelysin and collagenase expression, versus TIMP, may define a pivotal role for these cytokines in the pathogenesis of rheumatoid arthritis.
|
1698773 |
1990 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In the RA joint tissues, activation of NF-kappaB is often observed together with high amounts of the proinflammatory cytokines tumor necrosis factor (TNF)alpha and interleukin (IL)-1beta.
|
20053934 |
2010 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
MicroRNA-125b negatively regulates expression of TNF-α, which plays a crucial role in RA pathogenesis.
|
27255643 |
2016 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Our results do not support a causal relationship between TNF expression, serum TNF-α levels, and RA on AD risk.
|
31587925 |
2019 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Neutrophils and peripheral blood mononuclear cells (PBMCs) were isolated from three patients diagnosed with RA and treated with various concentrations of IGU, methotrexate (MTX), or dexamethasone (DXM) or without any drugs as a control for 8 h. The levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and IL-8 in culture supernatants were tested by ELISA.
|
31758423 |
2020 |